Do I need to delete unsubscribes or bounces from my list when I want to send another email?

Once an email addresses bounces or unsubscribes, the address will be visibly 'marked' on all your lists as unsubscribed or bounced. These addresses will be filtered from any future emails sent from your account and these records will be rejected from future imports into new or existing lists.
 
If you wish to trim your list size you may use the Mass Delete tool associated with your Master List to remove records but VerticalResponse will never mail to a record that has been marked as bounced or unsubscribed.